In vitro activity of chloroquine, quinine, mefloquine and halofantrine against Gabonese isolates of Plasmodium falciparum
نویسندگان
چکیده
منابع مشابه
In Vitro Activity of Mefloquine and its Enantiomers Against Plasmodium falciparum
The in vitro activity of rac-mefloquine hydrochloride and its pure enantiomers was tested against a chloroquine-resistant (PF.IBS2) strain of Plasmodium falciparum. The parasite isolated from Iranian patients was cultured in vitro by the candle jar method described by Tranger and Jensen and was exposed to the racemic mefloquine or its enantiomers over the concentration range of 10-9 to 10-4 M. ...
متن کاملDecreased in vitro susceptibility of Plasmodium falciparum isolates to artesunate, mefloquine, chloroquine, and quinine in Cambodia from 2001 to 2007.
This study describes the results of in vitro antimalarial susceptibility assays and molecular polymorphisms of Plasmodium falciparum isolates from Cambodia. The samples were collected from patients enrolled in therapeutic efficacy studies (TES) conducted by the Cambodian National Malaria Control Program for the routine efficacy monitoring of artemisinin-based combination therapy (ACT) (artesuna...
متن کاملFerrocene-chloroquine analogues as antimalarial agents: in vitro activity of ferrochloroquine against 103 Gabonese isolates of Plasmodium falciparum.
The in vitro activities of ferrochloroquine, chloroquine, quinine, mefloquine, halofantrine, amodiaquine, primaquine, atovaquone and artesunate were evaluated against Plasmodium falciparum isolates from children with uncomplicated malaria from Libreville (Gabon), using an isotopic, micro, drug susceptibility test. The IC(50) values for ferrochloroquine were in the range 0.43-30.9 nM and the geo...
متن کاملIn vitro sensitivity of Plasmodium falciparum isolates in Thailand to quinine and chloroquine, 1984-1990.
Until now, quinine has been used worldwide as the drug of choice for the emergency treatment of severe and complicated malaria. In fact, the long standing dependability of quinine has created a context of clinical confidence and reduced the per ceived threat of P. Jalciparum recrudescence where quinine and quinidine are available. However, in a situation of substantial loss of efficacy, it is...
متن کاملIn vitro interactions of artemisinin with atovaquone, quinine, and mefloquine against Plasmodium falciparum.
The interactions of artemisinin with atovaquone, quinine, and mefloquine were investigated in three Plasmodium falciparum strains (strains F-32, FCR-3, and K-1) by an in vitro culture assay. The parasites were cultured for 48 h in the presence of different concentrations and proportions of two drugs at a time in a checkerboard design. The response parameters were determined, and the sums of the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Tropical Medicine and International Health
سال: 2003
ISSN: 1360-2276,1365-3156
DOI: 10.1046/j.1365-3156.2003.00967.x